참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | Sodium Azide | HCID 33557 | — |
| 반응물 | (R)-tert-butyldimethyl(2-(oxiran-2-yl)ethoxy)silane | HCID 11030897 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Rac-1-azido-4-(tert-butyl-dimethyl-silanyloxy)-butan-2-ol | HCID 91149373 | 81% |
반응 단계
A solution of 2-[2-[[(tert-butyl)dimethylsilyl]oxy]ethyl]-oxirane (5.0 g; prepared according to WO 2007/144423) in MeOH (150 mL) was reacted with NaN3 (3.95 g) and NH4Cl (2.37 g). The reaction mixture was further stirred at 80° C. overnight. The solvent was evaporated under reduced pressure and the residue was partitioned between EA and water. The org. layer was washed with brine, dried over Na2SO4 and evaporated under reduced pressure, affording a yellow oil (4.9 g; 81% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08618092B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_12 |
|---|
| ORD ID | ord-333cec5958144505a623eb4ab2d6f229 |
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| 출처 메모 | uspto-grants-2013_12 |
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