反应详情

A solution of 2-[4-[(tert-butyl)dimethylsiloxy]butyl]oxirane (10.0 g) and 6-amino-4H-benzo[1,4]thiazin-3-one (7.81 g; commercial) in EtOH/water (300 mL; 9:1) was refluxed for 2 days. The solvents were removed under reduced pressure and the residue was taken up in EA/Hex (1:1; 100 mL) and filtered. The filtrate was concentrated under reduced pressure and purified by CC (EA/Hex; 1:1), affording an orange solid (7.40 g; 42% yield).

1. customThe solvents were removed under reduced pressure
2. filtrationfiltered
3. concentrationThe filtrate was concentrated under reduced pressure
4. custompurified by CC (EA/Hex; 1:1)
5. customaffording an orange solid (7.40 g; 42% yield)