HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol--water (1/1) → Methyl 3-amino-5-bromothiophene-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol--water (1/1) | HCID 22242641 | — |
| Reactant | Methyl 5-bromo-3-(2,2,2-trifluoroacetamido)thiophene-2-carboxylate | HCID 56965789 | — |
| Solvent | Potassium Carbonate | HCID 11430 | — |
| Product | Methyl 3-amino-5-bromothiophene-2-carboxylate | HCID 20158931 | 100% |
Reaction Steps
Methyl 5-bromo-3-(trifluoroacetylamino)-2-thiophenecarboxylate (2.0 g, 6.2 mmol) was stirred in 120 mL of 0.25 N K2CO3 in 7:3 MeOH/water. After 2.5 h, the bulk of the MeOH was removed in vacuo. The residue was partitioned between brine (75 mL) and CH2Cl2 (100 mL). The organic layer was dried (MgSO4) and concentrated in vacuo to provide methyl 5-bromo-3-amino-2-thiophenecarboxylate as a yellow solid (1.4 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618115B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-35954111250448da81286aa2ce179c1a |
| Source note | uspto-grants-2013_12 |