tert-Butyl [4-(hydroxymethyl)benzyl]carbamate → tert-Butyl hydrogen ((4-formylphenyl)methyl)carbonimidate

Participants

Reaction Steps

To an ethyl acetate (50 mL) solution of tert-butyl [4-(hydroxymethyl)benzyl]carbamate (3.0 g), manganese dioxide (20.0 g) was added. The reaction solution was stirred at room temperature for one hour. The reaction solution was filtered through celite (trade name). The filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography (n-hexane:ethyl acetate=8:2→7:3) to obtain the title compound having the following physical properties (2.3 g).

Provenance & Evidence