HCID 66845407, compound → HCID 66845336, compound

Participants

Reaction Steps

(R)-tert-Butyl 4-(7-(4-bromobenzoyloxy)-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazine-1-carboxylate (0.832 g, 1.608 mmol) was subjected to chromatography on SiO2 eluting with 2:1 hexanes:ethyl acetate to give tert-butyl 4-((5R,7R)-7-(4-bromobenzoyloxy)-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazine-1-carboxylate (0.31 g, 37%); then switching to 1:1 hexane:ethyl acetate to give tert-butyl 4-((5R,7S)-7-(4-bromobenzoyloxy)-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazine-1-carboxylate (415.3 mg, 49%).

Provenance & Evidence