HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1916516Generated: November 2, 2026
Trimethylsilylacetylene → HCID 14572730, compound
https://huagongshe.com/reaction/1916516
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trimethylsilylacetylene | HCID 66111 | — |
| Reactant | 2-(4-bromophenoxy)-N,N-diethylethanamine | HCID 423953 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Piperidine | HCID 8082 | — |
| Product | HCID 14572730 | HCID 14572730 | — |
Reaction Steps
Under a nitrogen atmosphere a mixture of 5.44 g (20 mmol) [2-(4-bromo-phenoxy)-ethyl]-diethyl-amine, 3.11 mL (22 mmol) ethynyl-trimethyl-silane, 462 mg (0.4 mmol) tetrakis-triphenylphosphane-palladium, 76 mg (0.4 mmol) CuI in 50 mL piperidine is heated to 70° C. for 21 h. The solvent is distilled off i.vac., the residue is taken up in water, exhaustively extracted with EtOAc and dried over Na2SO4. After the desiccant and solvent have been eliminated the residue is purified on silica gel (EtOAc/MeOH/NH3 95:5:0.5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08618132B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-b09d235c50064f6bb881e543d8f60808 |
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| Source note | uspto-grants-2013_12 |
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