HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → 1-(4-Bromobenzyl)pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 4-Bromobenzyl bromide | HCID 68527 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(4-Bromobenzyl)pyrrolidine | HCID 12738004 | — |
Reaction Steps
A solution of 12.5 g (50 mmol) 4-bromobenzylbromide is slowly added dropwise to a solution of 4.52 mL (55 mmol) pyrrolidine and 10.3 mL (60 mmol) ethyldiisopropylamine in 100 mL THF and stirred overnight at RT. The precipitate is filtered off and the solvent is eliminated i.vac. The product is obtained as a light-brown liquid which is further reacted without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618132B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-5d2c819c58c843bb9f02d11482261d21 |
| Source note | uspto-grants-2013_12 |