HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Pyrrolidin-1-ylmethyl-phenyl)-prop-2-yn-1-ol → 3-(4-Pyrrolidin-1-ylmethyl-phenyl)-propan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Pyrrolidin-1-ylmethyl-phenyl)-prop-2-yn-1-ol | HCID 61539089 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(4-Pyrrolidin-1-ylmethyl-phenyl)-propan-1-ol | HCID 67365322 | — |
Reaction Steps
A solution of 1.65 g (7.66 mmol) 3-(4-pyrrolidin-1-ylmethyl-phenyl)-prop-2-yn-1-ol in 20 mL EtOH is combined with 200 mg 10% Pd/C and hydrogenated in the autoclave at RT and 30 psi H2 until the theoretical uptake of hydrogen is achieved. The catalyst is suction filtered, the filtrate concentrated by evaporation and the residue is purified on silica gel (EtOAc/MeOH/NH3 90:10:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618132B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-32052be004b84210aea0c0f49242afb5 |
| Source note | uspto-grants-2013_12 |