HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1916537Erstellt: 25. Oktober 2026
2,5-Dibromopyridine → {4-[4-(5-Bromo-pyridin-2-yl)-but-3-ynyl]-phenyl}-methanol
https://huagongshe.com/reaction/1916537
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 2,5-Dibromopyridine | HCID 69353 | — |
| Edukt | 4-(3-Butyn-1-yl)benzenemethanol | HCID 23596609 | — |
| Katalysator | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Katalysator | HCID 178418476 | HCID 178418476 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Lösungsmittel | Triethylamine | HCID 8471 | — |
| Produkt | {4-[4-(5-Bromo-pyridin-2-yl)-but-3-ynyl]-phenyl}-methanol | HCID 69070552 | — |
Reaktionsschritte
Under an N2 atmosphere 130 mg (0.67 mmol) CuI and 300 mg (0.42 mmol) Pd(PPh3)2Cl2 are added to a solution of 2.0 g (12.48 mmol) (4-but-3-ynyl-phenyl)-methanol and 3.2 g (13.1 mmol) 2,5-dibromopyridine in 80 mL triethylamine and the reaction mixture is stirred for 1.5 h at 50° C. The solvent is eliminated in vacuo, the residue dissolved in a little DCM and purified by chromatography on silica gel (gradient: cyc/EtOAc 4:1 to cyc/EtOAc 3:1).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US08618132B2 |
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| Quelldatensatz | uspto-grants-2013_12 |
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| ORD ID | ord-6b15665bd4dd4132a87207ea712638f1 |
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| Quellennotiz | uspto-grants-2013_12 |
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