5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 10322966, compound

HRID 1916556Notes

Reaction equation

HRID 1916556 reaction equation
[Br:1][C:2]1[CH:15]=[C:14](I)[CH:13]=[CH:12][C:3]=1[O:4][CH2:5][CH2:6][N:7]1[CH2:11][CH2:10][CH2:9][CH2:8]1.[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:25]=[CH:26][C:27]([C:30]#[CH:31])=[N:28][CH:29]=2)=[CH:20][CH:19]=1>>[Br:1][C:2]1[CH:15]=[C:14]([C:31]#[C:30][C:27]2[CH:26]=[CH:25][C:24]([C:21]3[CH:22]=[CH:23][C:18]([Cl:17])=[CH:19][CH:20]=3)=[CH:29][N:28]=2)[CH:13]=[CH:12][C:3]=1[O:4][CH2:5][CH2:6][N:7]1[CH2:11][CH2:10][CH2:9][CH2:8]1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 67363137HCID 67363137, compound

Product 1

HCID 10322966HCID 10322966, compound

Procedure

Prepared according to general working method I from 1-[2-(2-bromo-4-iodo-phenoxy)-ethyl]-pyrrolidine (278 mg, 0.34 mmol, 70%) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (110 mg, 0.52 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-5bb482f2325e4ad686d9dbcf5a0eeb21
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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