5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 10073462, compound

HRID 1916558Notes

Reaction equation

HRID 1916558 reaction equation
I[C:2]1[CH:15]=[CH:14][C:5]([O:6][CH2:7][CH2:8][N:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)=[C:4]([C:16]([F:19])([F:18])[F:17])[CH:3]=1.[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]2[CH:28]=[CH:29][C:30]([C:33]#[CH:34])=[N:31][CH:32]=2)=[CH:23][CH:22]=1>>[Cl:20][C:21]1[CH:22]=[CH:23][C:24]([C:27]2[CH:28]=[CH:29][C:30]([C:33]#[C:34][C:2]3[CH:15]=[CH:14][C:5]([O:6][CH2:7][CH2:8][N:9]4[CH2:13][CH2:12][CH2:11][CH2:10]4)=[C:4]([C:16]([F:19])([F:18])[F:17])[CH:3]=3)=[N:31][CH:32]=2)=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69077004HCID 69077004, compound

Product 1

HCID 10073462HCID 10073462, compound

Procedure

Prepared according to general working method I from 1-[2-(4-iodo-2-trifluoromethyl-phenoxy)-ethyl]-pyrrolidine (180 mg, 0.47 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (83 mg, 0.39 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-4873b6dc1fea4cc0a1f95704c6bbc858
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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