5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 10069717, compound

HRID 1916561Notes

Reaction equation

HRID 1916561 reaction equation
I[C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[O:5][CH2:6][CH2:7][N:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:24]=[CH:25][C:26]([C:29]#[CH:30])=[N:27][CH:28]=2)=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([C:23]2[CH:24]=[CH:25][C:26]([C:29]#[C:30][C:2]3[CH:15]=[CH:14][CH:13]=[C:4]([O:5][CH2:6][CH2:7][N:8]4[CH2:12][CH2:11][CH2:10][CH2:9]4)[CH:3]=3)=[N:27][CH:28]=2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 60772709HCID 60772709, compound

Product 1

HCID 10069717HCID 10069717, compound

Procedure

Prepared according to general working method I from 1-[2-(3-iodo-phenoxy)-ethyl]-pyrrolidine (119 mg, 0.37 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (80 mg, 0.37 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-5d6802d776e94ac59dd1c66057896cad
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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