5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 10049301, compound

HRID 1916563Notes

Reaction equation

HRID 1916563 reaction equation
I[C:2]1[CH:15]=[CH:14][C:5]([O:6][CH2:7][CH2:8][N:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)=[C:4]([N+:16]([O-:18])=[O:17])[CH:3]=1.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[CH:27]=[CH:28][C:29]([C:32]#[CH:33])=[N:30][CH:31]=2)=[CH:22][CH:21]=1>>[Cl:19][C:20]1[CH:21]=[CH:22][C:23]([C:26]2[CH:27]=[CH:28][C:29]([C:32]#[C:33][C:2]3[CH:15]=[CH:14][C:5]([O:6][CH2:7][CH2:8][N:9]4[CH2:13][CH2:12][CH2:11][CH2:10]4)=[C:4]([N+:16]([O-:18])=[O:17])[CH:3]=3)=[N:30][CH:31]=2)=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69075308HCID 69075308, compound

Product 1

HCID 10049301HCID 10049301, compound

Procedure

Prepared according to general working method I from 1-[2-(4-iodo-2-nitro-phenoxy)-ethyl]-pyrrolidine (600 mg, 1.66 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (363 mg, 1.70 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-58617ff15dd246d380509ed1f86fbcc6
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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