HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Benzoic acid, 2-hydroxy-5-iodo-3-methyl-, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Hydroxy-5-iodo-3-methylbenzoic acid | HCID 15908685 | — |
| Product | Benzoic acid, 2-hydroxy-5-iodo-3-methyl-, methyl ester | HCID 14172484 | — |
Reaction Steps
A solution of 2.0 g (7.19 mmol) 2-hydroxy-5-iodo-3-methyl-benzoic acid in 5.0 mL thionyl chloride (69.0 mmol) is stirred for 20 min at 80° C. Thionyl chloride is eliminated i.vac. and the residue is combined with 20 mL MeOH and stirred for 20 min at RT. The product is precipitated out of the reaction. MeOH is eliminated i.vac. down to 5 mL and the residue is suction filtered. The product is further reacted without any more purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618132B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-14bc186e27e24c299a0c3914c5a30543 |
| Source note | uspto-grants-2013_12 |