5-(4-Chloro-phenyl)-2-ethynyl-pyridine → 5-(4-Chloro-phenyl)-2-[4-(1-ethyl-piperidin-3-yloxy)-phenylethynyl]-pyridine

HRID 1916574Notes

Reaction equation

Br[C:2]1[CH:16]=[CH:15][C:5]([O:6][CH:7]2[CH2:12][CH2:11][CH2:10][N:9]([CH2:13][CH3:14])[CH2:8]2)=[CH:4][CH:3]=1.[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:25]=[CH:26][C:27]([C:30]#[CH:31])=[N:28][CH:29]=2)=[CH:20][CH:19]=1>>[Cl:17][C:18]1[CH:19]=[CH:20][C:21]([C:24]2[CH:25]=[CH:26][C:27]([C:30]#[C:31][C:2]3[CH:16]=[CH:15][C:5]([O:6][CH:7]4[CH2:12][CH2:11][CH2:10][N:9]([CH2:13][CH3:14])[CH2:8]4)=[CH:4][CH:3]=3)=[N:28][CH:29]=2)=[CH:22][CH:23]=1

Participants

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridine

HCID 673628503-(4-Bromo-phenoxy)-1-ethyl-piperidine

Product 1

HCID 103646285-(4-Chloro-phenyl)-2-[4-(1-ethyl-piperidin-3-yloxy)-phenylethynyl]-pyridine

Procedure

Prepared according to general working method I from 3-(4-bromo-phenoxy)-1-ethyl-piperidine (90 mg, 0.32 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (68 mg, 0.32 mmol).

Workup

customPrepared

Sources & evidence

ORD record: ord-e6bdb6eb14f1480c847585639110ba1a
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08618132B2

Reaction notes

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