5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 10001870, compound

HRID 1916575Notes

Reaction equation

HRID 1916575 reaction equation
Br[C:2]1[CH:16]=[CH:15][C:5]([O:6][C@H:7]2[CH:12]3[CH2:13][CH2:14][N:9]([CH2:10][CH2:11]3)[CH2:8]2)=[CH:4][CH:3]=1.[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:25]=[CH:26][C:27]([C:30]#[CH:31])=[N:28][CH:29]=2)=[CH:20][CH:19]=1>>[Cl:17][C:18]1[CH:19]=[CH:20][C:21]([C:24]2[CH:25]=[CH:26][C:27]([C:30]#[C:31][C:2]3[CH:16]=[CH:15][C:5]([O:6][C@H:7]4[CH:12]5[CH2:13][CH2:14][N:9]([CH2:10][CH2:11]5)[CH2:8]4)=[CH:4][CH:3]=3)=[N:28][CH:29]=2)=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 67363810HCID 67363810, compound

Product 1

HCID 10001870HCID 10001870, compound

Procedure

Prepared according to general working method I from (S)-3-(4-bromo-phenoxy)-1-aza-bicyclo[2.2.2]octane (170 mg, 0.62 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (100 mg, 0.47 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-8c5f81f9070a4af89841dd9d4c6e6f4f
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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