5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 10342384, compound

HRID 1916576Notes

Reaction equation

HRID 1916576 reaction equation
I[C:2]1[CH:17]=[CH:16][C:5]([O:6][CH2:7][CH2:8][NH:9][C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:26]=[CH:27][C:28]([C:31]#[CH:32])=[N:29][CH:30]=2)=[CH:21][CH:20]=1>>[Cl:18][C:19]1[CH:20]=[CH:21][C:22]([C:25]2[CH:26]=[CH:27][C:28]([C:31]#[C:32][C:2]3[CH:17]=[CH:16][C:5]([O:6][CH2:7][CH2:8][NH:9][C:10]4[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=4)=[CH:4][CH:3]=3)=[N:29][CH:30]=2)=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69076959HCID 69076959, compound

Product 1

HCID 10342384HCID 10342384, compound

Procedure

Prepared according to general working method I from [2-(4-iodo-phenoxy)-ethyl]-pyridin-4-yl-amine (95 mg, 0.28 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (70 mg, 0.33 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-e86a5a98cf4b4da9ab1859d1162a9f6f
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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