5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 10344765, compound

HRID 1916577Notes

Reaction equation

I[C:2]1[CH:20]=[CH:19][C:5]([O:6][CH2:7][CH2:8][N:9]2[C:14]([CH3:16])([CH3:15])[CH2:13][CH2:12][CH2:11][C:10]2([CH3:18])[CH3:17])=[CH:4][CH:3]=1.[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:29]=[CH:30][C:31]([C:34]#[CH:35])=[N:32][CH:33]=2)=[CH:24][CH:23]=1>>[Cl:21][C:22]1[CH:23]=[CH:24][C:25]([C:28]2[CH:29]=[CH:30][C:31]([C:34]#[C:35][C:2]3[CH:20]=[CH:19][C:5]([O:6][CH2:7][CH2:8][N:9]4[C:14]([CH3:16])([CH3:15])[CH2:13][CH2:12][CH2:11][C:10]4([CH3:18])[CH3:17])=[CH:4][CH:3]=3)=[N:32][CH:33]=2)=[CH:26][CH:27]=1

Participants

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridine

HCID 69072411HCID 69072411, compound

Product 1

HCID 10344765HCID 10344765, compound

Procedure

Prepared according to general working method I from 1-[2-(4-iodo-phenoxy)-ethyl]-2,2,6,6-tetramethyl-piperidine (260 mg, 0.67 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (155 mg, 0.73 mmol).

Workup

customPrepared

Sources & evidence

ORD record: ord-18c261222a42497f86b55997e0819e7d
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08618132B2

Reaction notes

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