5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 69076479, compound

HRID 1916585Notes

Reaction equation

HRID 1916585 reaction equation
I[C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:13][C@H:12]3[CH2:14][C@H:9]2[N:10]([CH3:15])[CH2:11]3)=[N:6][CH:7]=1.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:24]=[CH:25][C:26]([C:29]#[CH:30])=[N:27][CH:28]=2)=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([C:23]2[CH:24]=[CH:25][C:26]([C:29]#[C:30][C:2]3[CH:3]=[CH:4][C:5]([N:8]4[CH2:13][C@H:12]5[CH2:14][C@H:9]4[N:10]([CH3:15])[CH2:11]5)=[N:6][CH:7]=3)=[N:27][CH:28]=2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69076370HCID 69076370, compound

Product 1

HCID 69076479HCID 69076479, compound

Procedure

Prepared according to general working method I from (1S,4S)-2-(5-iodo-pyridin-2-yl)-6-methyl-2,6-diaza-bicyclo[2.2.1]heptane (45 mg, 0.14 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (51 mg, 0.24 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-ab23846505f049648987d146c540c471
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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