5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 59835790, compound

HRID 1916586Notes

Reaction equation

HRID 1916586 reaction equation
I[C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH3:16])[CH2:9][CH2:10][N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[N:6][CH:7]=1.[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:25]=[CH:26][C:27]([C:30]#[CH:31])=[N:28][CH:29]=2)=[CH:20][CH:19]=1>>[Cl:17][C:18]1[CH:19]=[CH:20][C:21]([C:24]2[CH:25]=[CH:26][C:27]([C:30]#[C:31][C:2]3[CH:3]=[CH:4][C:5]([N:8]([CH3:16])[CH2:9][CH2:10][N:11]4[CH2:15][CH2:14][CH2:13][CH2:12]4)=[N:6][CH:7]=3)=[N:28][CH:29]=2)=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69076578HCID 69076578, compound

Product 1

HCID 59835790HCID 59835790, compound

Procedure

Prepared according to general working method I from (5-iodo-pyridin-2-yl)-methyl-(2-pyrrolidin-1-yl-ethyl)-amine (100 mg, 0.30 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (65 mg, 0.30 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-c2416e5bed774b0f854c3bb49fc742a2
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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