5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 10363776, compound

HRID 1916588Notes

Reaction equation

HRID 1916588 reaction equation
I[C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]([CH3:15])[CH3:14])[CH2:9]2)=[N:6][CH:7]=1.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:24]=[CH:25][C:26]([C:29]#[CH:30])=[N:27][CH:28]=2)=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([C:23]2[CH:24]=[CH:25][C:26]([C:29]#[C:30][C:2]3[CH:3]=[CH:4][C:5]([N:8]4[CH2:12][CH2:11][CH:10]([N:13]([CH3:15])[CH3:14])[CH2:9]4)=[N:6][CH:7]=3)=[N:27][CH:28]=2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 690759961-(5-Iodo-2-pyridinyl)-N,N-dimethyl-3-pyrrolidinamine

Product 1

HCID 10363776HCID 10363776, compound

Procedure

Prepared according to general working method I from [1-(5-iodo-pyridin-2-yl)-pyrrolidin-3-yl]-dimethyl-amine (160 mg, 0.50 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (108 mg, 0.50 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-bae08b1317d94dbdac1a368f22ee9023
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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