5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 11744099, compound

HRID 1916593Notes

Reaction equation

HRID 1916593 reaction equation
I[C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][CH2:11][CH:10]([N:14]3[CH2:18][CH2:17][CH2:16][CH2:15]3)[CH2:9]2)=[N:6][CH:7]=1.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[CH:27]=[CH:28][C:29]([C:32]#[CH:33])=[N:30][CH:31]=2)=[CH:22][CH:21]=1>>[Cl:19][C:20]1[CH:21]=[CH:22][C:23]([C:26]2[CH:27]=[CH:28][C:29]([C:32]#[C:33][C:2]3[CH:3]=[CH:4][C:5]([N:8]4[CH2:13][CH2:12][CH2:11][CH:10]([N:14]5[CH2:18][CH2:17][CH2:16][CH2:15]5)[CH2:9]4)=[N:6][CH:7]=3)=[N:30][CH:31]=2)=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69077904HCID 69077904, compound

Product 1

HCID 11744099HCID 11744099, compound

Procedure

Prepared according to general working method I from 5′-iodo-3-pyrrolidin-1-yl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl (179 mg, 0.50 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (107 mg, 0.50 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-acd2b2ddb7804481806e1f09efe0d4b2
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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