HuagongsheHuagongshe Chemistry Print Report · For research reference only
1'-Benzyl-[1,3']bipyrrolidinyl → 1-(Pyrrolidin-3-yl)pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1'-Benzyl-[1,3']bipyrrolidinyl | HCID 23145923 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(Pyrrolidin-3-yl)pyrrolidine | HCID 14627375 | — |
Reaction Steps
180 mg 10% Pd/C are added to a solution of 1.80 g (7.42 mmol) 1′-benzyl-[1,3′]bipyrrolidinyl in 80 mL MeOH. The reaction solution is stirred for 5 h at RT and at 3 bar H2. Another 180 mg 10% Pd/C are added and after 4 h 100 mg palladium hydroxide are added. The reaction is stirred for a further 6 h at RT and at 3 bar H2. The catalyst is suction filtered and the solvent is eliminated i.vac.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618132B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-01354f89aa964ca2955a783d701be38c |
| Source note | uspto-grants-2013_12 |