5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 10048253, compound

HRID 1916596Notes

Reaction equation

HRID 1916596 reaction equation
I[C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]3[CH2:17][CH2:16][CH2:15][CH2:14]3)[CH2:9]2)=[N:6][CH:7]=1.[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:26]=[CH:27][C:28]([C:31]#[CH:32])=[N:29][CH:30]=2)=[CH:21][CH:20]=1>>[Cl:18][C:19]1[CH:20]=[CH:21][C:22]([C:25]2[CH:26]=[CH:27][C:28]([C:31]#[C:32][C:2]3[CH:3]=[CH:4][C:5]([N:8]4[CH2:12][CH2:11][CH:10]([N:13]5[CH2:17][CH2:16][CH2:15][CH2:14]5)[CH2:9]4)=[N:6][CH:7]=3)=[N:29][CH:30]=2)=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69076011HCID 69076011, compound

Product 1

HCID 10048253HCID 10048253, compound

Procedure

Prepared according to general working method I from 1′-(5-iodo-pyridin-2-yl)-[1,3′]bipyrrolidinyl (172 mg, 0.50 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (107 mg, 0.50 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-50d0d0e4f17d4e42b960fed0a427820a
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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