5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 9979335, compound

HRID 1916600Notes

Reaction equation

HRID 1916600 reaction equation
I[C:2]1[CH:3]=[CH:4][C:5]([NH:8][CH2:9][CH:10]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[CH3:11])=[N:6][CH:7]=1.[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:25]=[CH:26][C:27]([C:30]#[CH:31])=[N:28][CH:29]=2)=[CH:20][CH:19]=1>>[Cl:17][C:18]1[CH:19]=[CH:20][C:21]([C:24]2[CH:25]=[CH:26][C:27]([C:30]#[C:31][C:2]3[CH:3]=[CH:4][C:5]([NH:8][CH2:9][CH:10]([N:12]4[CH2:16][CH2:15][CH2:14][CH2:13]4)[CH3:11])=[N:6][CH:7]=3)=[N:28][CH:29]=2)=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69076957HCID 69076957, compound

Product 1

HCID 9979335HCID 9979335, compound

Procedure

Prepared according to general working method I from (5-iodo-pyridin-2-yl)-(2-pyrrolidin-1-yl-propyl)-amine (250 mg, 0.76 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (165 mg, 0.77 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-47b3dcdee2384b07aba49aa3dad2a83c
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

Loading…