5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 10388657, compound

HRID 1916605Notes

Reaction equation

HRID 1916605 reaction equation
I[C:2]1[CH:18]=[CH:17][C:5]2[N:6]([CH2:10][CH2:11][N:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)[C:7](=[O:9])[NH:8][C:4]=2[CH:3]=1.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[CH:27]=[CH:28][C:29]([C:32]#[CH:33])=[N:30][CH:31]=2)=[CH:22][CH:21]=1>>[Cl:19][C:20]1[CH:21]=[CH:22][C:23]([C:26]2[CH:27]=[CH:28][C:29]([C:32]#[C:33][C:2]3[CH:18]=[CH:17][C:5]4[N:6]([CH2:10][CH2:11][N:12]5[CH2:16][CH2:15][CH2:14][CH2:13]5)[C:7](=[O:9])[NH:8][C:4]=4[CH:3]=3)=[N:30][CH:31]=2)=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69075818HCID 69075818, compound

Product 1

HCID 10388657HCID 10388657, compound

Procedure

Prepared according to general working method I from 5-iodo-1-(2-pyrrolidin-1-yl-ethyl)-1,3-dihydro-benzimidazol-2-one (140 mg, 0.39 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (83 mg, 0.39 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-5124c2b366fa4b47a82c6df0f1fdcc02
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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