Thionyl Chloride → HCID 178526480, compound

HRID 1916613Notes

Reaction equation

HRID 1916613 reaction equation
S(Cl)([Cl:3])=O.[N+:5]([C:8]1[CH:18]=[CH:17][C:11]2[NH:12][C:13]([CH2:15]O)=[N:14][C:10]=2[CH:9]=1)([O-:7])=[O:6]>C(Cl)Cl>[Cl:3][CH2:15][C:13]1[NH:12][C:11]2[CH:17]=[CH:18][C:8]([N+:5]([O-:7])=[O:6])=[CH:9][C:10]=2[N:14]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 178526485HCID 178526485, compound

Product 1

HCID 178526480HCID 178526480, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

20 mL (275 mmol) thionyl chloride are added slowly to a solution of 6.4 g (33.1 mmol) (5-nitro-1H-benzimidazol-2-yl)-methanol in 100 mL DCM at 10° C. The reaction is stirred for 1 h at RT and the solvent is eliminated i.vac. The residue is triturated with DCM, suction filtered, washed with DCM and ether and dried in the circulating air dryer at 35° C.

Workup

  1. customThe residue is triturated with DCM, suction
  2. filtrationfiltered
  3. washwashed with DCM and ether
  4. customdried in the circulating air dryer at 35° C.

Sources & evidence

ORD record
ord-fe9725935a4141bb81ed434a33516a6e
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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