5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 178477939, compound

HRID 1916617Notes

Reaction equation

HRID 1916617 reaction equation
I[C:2]1[CH:16]=[CH:15][C:5]2[NH:6][C:7]([CH2:9][N:10]3[CH2:14][CH2:13][CH2:12][CH2:11]3)=[N:8][C:4]=2[CH:3]=1.[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:25]=[CH:26][C:27]([C:30]#[CH:31])=[N:28][CH:29]=2)=[CH:20][CH:19]=1>>[Cl:17][C:18]1[CH:19]=[CH:20][C:21]([C:24]2[CH:25]=[CH:26][C:27]([C:30]#[C:31][C:2]3[CH:16]=[CH:15][C:5]4[NH:6][C:7]([CH2:9][N:10]5[CH2:14][CH2:13][CH2:12][CH2:11]5)=[N:8][C:4]=4[CH:3]=3)=[N:28][CH:29]=2)=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 178506538HCID 178506538, compound

Product 1

HCID 178477939HCID 178477939, compound

Procedure

Prepared according to general working method I from 5-iodo-2-pyrrolidin-1-ylmethyl-1H-benzimidazole (200 mg, 0.61 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (131 mg, 0.61 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-62cfd8339a8c428083105f468a21ff17
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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