5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 10387443, compound

HRID 1916625Notes

Reaction equation

HRID 1916625 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][C:15]=1I)[O:5][CH2:6][CH2:7][N:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1.[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:25]=[CH:26][C:27]([C:30]#[CH:31])=[N:28][CH:29]=2)=[CH:20][CH:19]=1>>[Cl:17][C:18]1[CH:19]=[CH:20][C:21]([C:24]2[CH:25]=[CH:26][C:27]([C:30]#[C:31][C:15]3[CH:14]=[CH:13][C:4]([O:5][CH2:6][CH2:7][N:8]4[CH2:12][CH2:11][CH2:10][CH2:9]4)=[CH:3][C:2]=3[F:1])=[N:28][CH:29]=2)=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 67362278HCID 67362278, compound

Product 1

HCID 10387443HCID 10387443, compound

Procedure

Prepared according to general working method I from 1-[2-(3-fluoro-4-iodo-phenoxy)-ethyl]-pyrrolidine (500 mg, 0.75 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (159 mg, 0.75 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-dce702af03944d4cbd0a5a1889ca8d45
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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