5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 67363454, compound

HRID 1916632Notes

Reaction equation

HRID 1916632 reaction equation
I[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([CH2:12][OH:13])[CH:6]=[CH:5]2.[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:22]=[CH:23][C:24]([C:27]#[CH:28])=[N:25][CH:26]=2)=[CH:17][CH:16]=1>>[Cl:14][C:15]1[CH:16]=[CH:17][C:18]([C:21]2[CH:22]=[CH:23][C:24]([C:27]#[C:28][C:2]3[CH:3]=[C:4]4[C:9](=[CH:10][CH:11]=3)[CH:8]=[C:7]([CH2:12][OH:13])[CH:6]=[CH:5]4)=[N:25][CH:26]=2)=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 58361291HCID 58361291, compound

Product 1

HCID 67363454HCID 67363454, compound

Procedure

Prepared according to general working method I from (6-iodo-naphthalen-2-yl)-methanol (450 mg, 1.58 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (342 mg, 1.60 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a899a211b0734fa9be5f2dd0548d0531
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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