HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(N-benzylpyrrolidin-3-yl)piperidine → 1-(Pyrrolidin-3-yl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(N-benzylpyrrolidin-3-yl)piperidine | HCID 18002297 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(Pyrrolidin-3-yl)piperidine | HCID 23009617 | — |
Reaction Steps
550 mg 10% Pd/C are added to a solution of 5.50 g (22.5 mmol) 1-(1-benzyl-pyrrolidin-3-yl)-piperidine in 200 mL MeOH. The reaction solution is stirred for 5 h at RT and 3 bar H2. 550 mg palladiumhydroxide are added and the reaction is stirred for a further 6 h at RT and 3 bar H2. The catalyst is suction filtered and the solvent is eliminated i.vac.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618132B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-e0f3b9cc56dd4206b0929a8296f40fe3 |
| Source note | uspto-grants-2013_12 |