5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 10478503, compound

HRID 1916641Notes

Reaction equation

HRID 1916641 reaction equation
I[C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]3[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]3)[CH2:9]2)=[CH:4][CH:3]=1.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[CH:27]=[CH:28][C:29]([C:32]#[CH:33])=[N:30][CH:31]=2)=[CH:22][CH:21]=1>>[Cl:19][C:20]1[CH:21]=[CH:22][C:23]([C:26]2[CH:27]=[CH:28][C:29]([C:32]#[C:33][C:2]3[CH:7]=[CH:6][C:5]([N:8]4[CH2:12][CH2:11][CH:10]([N:13]5[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]5)[CH2:9]4)=[CH:4][CH:3]=3)=[N:30][CH:31]=2)=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69079705HCID 69079705, compound

Product 1

HCID 10478503HCID 10478503, compound

Procedure

Prepared according to general working method I from 1-[1-(4-iodo-phenyl)-pyrrolidin-3-yl]-piperidine (120 mg, 0.34 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (73 mg, 0.34 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f46d235fc1164fbfad687a0356c2dcbe
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

Loading…