HCID 12118321, compound → HCID 59835871, compound

HRID 1916643Notes

Reaction equation

HRID 1916643 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:9][CH2:10][N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:4][N:3]=1.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:24]=[CH:25][C:26]([C:29]#[CH:30])=[N:27][CH:28]=2)=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([C:23]2[CH:24]=[CH:25][C:26]([C:29]#[C:30][C:2]3[CH:7]=[CH:6][C:5]([O:8][CH2:9][CH2:10][N:11]4[CH2:15][CH2:14][CH2:13][CH2:12]4)=[CH:4][N:3]=3)=[N:27][CH:28]=2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 12118321HCID 12118321, compoundHCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridine

Product 1

HCID 59835871HCID 59835871, compound

Procedure

Prepared according to general working method I from 2-bromo-5-(2-pyrrolidin-1-yl-ethoxy)-pyridine (271 mg, 0.50 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (106 mg, 0.50 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-c8c13c917aab46dd9ec6865003af5c98
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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