5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 10071209, compound

HRID 1916644Notes

Reaction equation

HRID 1916644 reaction equation
I[C:2]1[CH:3]=[CH:4][C:5]([O:10][CH2:11][CH2:12][N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)=[C:6]([CH:9]=1)[C:7]#[N:8].[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:26]=[CH:27][C:28]([C:31]#[CH:32])=[N:29][CH:30]=2)=[CH:21][CH:20]=1>>[Cl:18][C:19]1[CH:20]=[CH:21][C:22]([C:25]2[CH:26]=[CH:27][C:28]([C:31]#[C:32][C:2]3[CH:3]=[CH:4][C:5]([O:10][CH2:11][CH2:12][N:13]4[CH2:17][CH2:16][CH2:15][CH2:14]4)=[C:6]([CH:9]=3)[C:7]#[N:8])=[N:29][CH:30]=2)=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69071631HCID 69071631, compound

Product 1

HCID 10071209HCID 10071209, compound

Procedure

Prepared according to general working method I from 5-iodo-2-(2-pyrrolidin-1-yl-ethoxy)-benzonitrile (300 mg, 0.88 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (206 mg, 0.97 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d2f1c0ed80634b3dbb8a53e25c0a48a6
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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