Ethyl bromoacetate → Ethyl (5-bromobenzofuran)-2-carboxylate

Participants

Reaction Conditions

Reaction Steps

13.8 g (100 mmol) Na2CO3 are added to a solution of 4.02 g (20.0 mmol) 5-bromo-salicylaldehyde and 2.26 mL (20.0 mmol, 98%) ethyl bromoacetate in 50 mL DMF. The reaction mixture is heated to 80° C. and stirred for 2 h at this temperature. It is diluted with 200 mL water, the aqueous phase is extracted three times with 100 mL tert-butylmethylether and the combined organic extracts are washed twice with 50 mL water. The organic phase is dried over MgSO4, filtered through activated charcoal and the solvent is eliminated i.vac.

Provenance & Evidence