5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 59835840, compound

HRID 1916657Notes

Reaction equation

HRID 1916657 reaction equation
I[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]([O:13][CH2:14][CH2:15][N:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1)=[O:12])[CH2:6][CH2:5]2.[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:29]=[CH:30][C:31]([C:34]#[CH:35])=[N:32][CH:33]=2)=[CH:24][CH:23]=1>>[Cl:21][C:22]1[CH:23]=[CH:24][C:25]([C:28]2[CH:29]=[CH:30][C:31]([C:34]#[C:35][C:2]3[CH:3]=[C:4]4[C:8](=[CH:9][CH:10]=3)[N:7]([C:11]([O:13][CH2:14][CH2:15][N:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)=[O:12])[CH2:6][CH2:5]4)=[N:32][CH:33]=2)=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69077334HCID 69077334, compound

Product 1

HCID 59835840HCID 59835840, compound

Procedure

Prepared according to general working method I from 2-pyrrolidin-1-yl-ethyl 5-iodo-2,3-dihydro-indole-1-carboxylate (120 mg, 0.31 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (80 mg, 0.37 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-540428cd32b94589813ee1a0e2124474
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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