HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-nitro-1-(2-pyrrolidin-1-yl-ethyl)-1H-indazole → 1-(2-Pyrrolidin-1-YL-ethyl)-1H-indazol-5-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-nitro-1-(2-pyrrolidin-1-yl-ethyl)-1H-indazole | HCID 22036579 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-(2-Pyrrolidin-1-YL-ethyl)-1H-indazol-5-ylamine | HCID 11310777 | — |
Reaction Steps
0.50 g Raney nickel are added to a solution of 3.50 g (13.4 mmol) 5-nitro-1-(2-pyrrolidin-1-yl-ethyl)-1H-indazole in 50 mL EtOAc and the reaction mixture is stirred for 20 h at RT at 1.4 bar H2. After filtration the solvent is eliminated i.vac. The product is further reacted without any more purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618132B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-bf897fffa7a9484e967c5bb41ad61533 |
| Source note | uspto-grants-2013_12 |