5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 10320296, compound

HRID 1916668Notes

Reaction equation

HRID 1916668 reaction equation
I[C:2]1[CH:10]=[CH:9][C:8]2[C:4](=[CH:5][N:6]([CH2:11][CH2:12][N:13]3[CH2:17][CH2:16][CH2:15][CH2:14]3)[N:7]=2)[CH:3]=1.[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:26]=[CH:27][C:28]([C:31]#[CH:32])=[N:29][CH:30]=2)=[CH:21][CH:20]=1>>[Cl:18][C:19]1[CH:20]=[CH:21][C:22]([C:25]2[CH:26]=[CH:27][C:28]([C:31]#[C:32][C:2]3[CH:10]=[CH:9][C:8]4[C:4](=[CH:5][N:6]([CH2:11][CH2:12][N:13]5[CH2:17][CH2:16][CH2:15][CH2:14]5)[N:7]=4)[CH:3]=3)=[N:29][CH:30]=2)=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69077610HCID 69077610, compound

Product 1

HCID 10320296HCID 10320296, compound

Procedure

Prepared according to general working method I from 5-iodo-2-(2-pyrrolidin-1-yl-ethyl)-2H-indazole (170 mg, 0.50 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (106 mg, 0.50 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-461b82a5fc0140a99c638b2ebf51a7d0
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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