Acetic Acid → 2-(Azetidin-3-yl)hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one

HRID 191667Notes

Reaction equation

HRID 191667 reaction equation
[CH3:28][C:29](=[O:30])[OH:31].[OH-:32].[OH-:34].[Pd+2:33].[c:1]1([CH:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:22]2)[N:8]2[CH2:9][CH:10]([N:12]3[CH2:13][CH:14]4[N:15]([CH2:16][CH2:17]3)[C:18](=[O:21])[CH2:19][CH2:20]4)[CH2:11]2)[cH:23][cH:24][cH:25][cH:26][cH:27]1>>[NH:8]1[CH2:9][CH:10]([N:12]2[CH2:13][CH:14]3[N:15]([CH2:16][CH2:17]2)[C:18](=[O:21])[CH2:19][CH2:20]3)[CH2:11]1

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 1401268702-(1-Benzhydrylazetidin-3-yl)-1,3,4,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-6-one

Product 1

HCID 694567392-(Azetidin-3-yl)hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one

Sources & evidence

ORD record
ord-bee35cfa2b314b25818323d529da383f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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