HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → 2-Bromo-5-(4-chloro-phenyl)-pyridin-3-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-Bromo-5-(4-chlorophenyl)-3-nitropyridine | HCID 85969699 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-Bromo-5-(4-chloro-phenyl)-pyridin-3-ylamine | HCID 85969704 | — |
Reaction Steps
A solution of 5.60 g (17.9 mmol) 2-bromo-5-(4-chloro-phenyl)-3-nitro-pyridine, 20.3 g (90.0 mmol) tin(II)-chloride and 18.9 g (225 mmol) NaHCO3 in 300 mL EtOAc is refluxed for 30 h. After filtration the solvent is eliminated i.vac. The residue is triturated with DCM and after filtration the filter residue is dried in the air.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618132B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-b841da7b84814a379a6b0c6a8e1534bf |
| Source note | uspto-grants-2013_12 |