5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 67363734, compound

HRID 1916682Notes

Reaction equation

HRID 1916682 reaction equation
I[C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][CH:8]([OH:10])[CH3:9])=[CH:4][CH:3]=1.[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:21]=[CH:22][C:23]([C:26]#[CH:27])=[N:24][CH:25]=2)=[CH:16][CH:15]=1>>[Cl:13][C:14]1[CH:15]=[CH:16][C:17]([C:20]2[CH:21]=[CH:22][C:23]([C:26]#[C:27][C:2]3[CH:12]=[CH:11][C:5]([O:6][CH2:7][CH:8]([OH:10])[CH3:9])=[CH:4][CH:3]=3)=[N:24][CH:25]=2)=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 65277775HCID 65277775, compound

Product 1

HCID 67363734HCID 67363734, compound

Procedure

Prepared according to general working method I from 1-(4-iodo-phenoxy)-propan-2-ol (2.00 g, 7.19 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (1.54 g, 7.20 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-55cec7362281483c9afd960e947dcf64
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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