5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 67363290, compound

HRID 1916685Notes

Reaction equation

HRID 1916685 reaction equation
I[C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:12][CH2:11][C@@H:10]([OH:13])[CH2:9]2)=[N:6][CH:7]=1.[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:22]=[CH:23][C:24]([C:27]#[CH:28])=[N:25][CH:26]=2)=[CH:17][CH:16]=1>>[Cl:14][C:15]1[CH:16]=[CH:17][C:18]([C:21]2[CH:22]=[CH:23][C:24]([C:27]#[C:28][C:2]3[CH:3]=[CH:4][C:5]([N:8]4[CH2:12][CH2:11][C@@H:10]([OH:13])[CH2:9]4)=[N:6][CH:7]=3)=[N:25][CH:26]=2)=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69069559(3R)-1-(5-Iodo-2-pyridinyl)-3-pyrrolidinol

Product 1

HCID 67363290HCID 67363290, compound

Procedure

Prepared according to general working method I from (R)-1-(5-iodo-pyridin-2-yl)-pyrrolidin-3-ol (1.30 g, 4.48 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (957 mg, 4.48 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f10a437d180f4514a239e9b077342f62
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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