1-Bromo-4-iodobenzene → 1-[3-(4-Bromo-phenyl)-prop-2-ynyl]-pyrrolidine

HRID 1916688Notes

Reaction equation

HRID 1916688 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5](I)=[CH:4][CH:3]=1.[CH2:9]([N:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1)[C:10]#[CH:11]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:11]#[C:10][CH2:9][N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 115221-Bromo-4-iodobenzeneHCID 2996161-(Prop-2-yn-1-yl)pyrrolidine

Product 1

HCID 690692661-[3-(4-Bromo-phenyl)-prop-2-ynyl]-pyrrolidine

Procedure

Prepared according to general working method I from 4-bromo-iodobenzene (10.9 g, 38.5 mmol) and 1-prop-2-ynyl-pyrrolidine (4.20 g, 71% purity, 27.3 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-98027cf1cce4421ca94befee45ce6029
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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