Methanesulfonyl chloride → 2-{4-[5-(4-Chlorophenyl)pyridin-2-ylethynyl]-2-methylphenoxy}ethyl methanesulfonate

HRID 1916702Notes

Reaction equation

HRID 1916702 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]([C:14]#[C:15][C:16]3[CH:25]=[CH:24][C:19]([O:20][CH2:21][CH2:22][OH:23])=[C:18]([CH3:26])[CH:17]=3)=[N:12][CH:13]=2)=[CH:4][CH:3]=1.[CH3:27][S:28](Cl)(=[O:30])=[O:29]>>[CH3:27][S:28]([O:23][CH2:22][CH2:21][O:20][C:19]1[CH:24]=[CH:25][C:16]([C:15]#[C:14][C:11]2[CH:10]=[CH:9][C:8]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=3)=[CH:13][N:12]=2)=[CH:17][C:18]=1[CH3:26])(=[O:30])=[O:29]

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 673624362-{4-[5-(4-Chlorophenyl)pyridin-2-ylethynyl]-2-methylphenoxy}ethanol

Product 1

HCID 865946832-{4-[5-(4-Chlorophenyl)pyridin-2-ylethynyl]-2-methylphenoxy}ethyl methanesulfonate

Procedure

Prepared analogously to Example 4.1a from 310 mg (0.93 mmol) 2-{4-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-2-methyl-phenoxy}-ethanol and 88 μL (1.12 mmol) methanesulphonic acid chloride.

Sources & evidence

ORD record
ord-483ed1dac19547ad9ccf2ccdfb5e303a
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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