Potassium Carbonate → HCID 85969576, compound

Participants

Reaction Steps

A solution of 250 mg (1.37 mmol) 1-prop-2-ynyl-1H-indole-5-carbaldehyde and 200 μL (2.37 mmol) pyrrolidine in 50 mL THF is adjusted to pH 5 with glacial acetic acid, combined with 550 mg (2.47 mmol) NaBH(OAc)3 and stirred for 24 h at RT. 20 mL of saturated K2CO3 solution are added, the mixture is extracted with 50 mL EtOAc and the organic phase is dried over Na2SO4. After the desiccant and solvent have been eliminated the residue is purified by chromatography (silica gel, EtOAc/MeOH/NH3 95:5:0.5).

Provenance & Evidence