反应详情

温度

110 °C

Under an N2 atmosphere 21.7 mL 2 M Na2CO3 solution and 250 mg (0.22 mmol) tetrakis-triphenylphosphane-palladium are added to a solution of 8.0 g (21.7 mmol) 5-iodo-pyridin-2-ol and 3.81 g (23.9 mmol) 4-chlorophenyl-boric acid in 120 mL 1,4-dioxane and 30 mL dry MeOH and the reaction mixture is stirred for 19 h at 110° C. The mixture is evaporated down i. vac., the residue is combined with water, the precipitate is filtered off, washed with water and dried at 40° C. in the circulating air dryer until a constant weight is obtained.

1. customThe mixture is evaporated down i
2. filtrationthe precipitate is filtered off
3. washwashed with water
4. customdried at 40° C. in the circulating air dryer until a constant weight
5. customis obtained