HuagongsheHuagongshe Chemistry Print Report · For research reference only
(5-Ethynyl-3-methyl-pyridin-2-yl)-(2-pyrrolidin-1-yl-ethyl)-amine → {5-[5-(4-Chloro-phenyl)-pyridin-2-ylethynyl]-3-methyl-pyridin-2-yl}-(2-pyrrolidin-1-yl-ethyl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (5-Ethynyl-3-methyl-pyridin-2-yl)-(2-pyrrolidin-1-yl-ethyl)-amine | HCID 85969677 | — |
| Reactant | 5-(4-Chlorophenyl)-2-iodopyridine | HCID 85969849 | — |
| Product | {5-[5-(4-Chloro-phenyl)-pyridin-2-ylethynyl]-3-methyl-pyridin-2-yl}-(2-pyrrolidin-1-yl-ethyl)-amine | HCID 59835837 | — |
Reaction Steps
Prepared analogously to Example 15e from 69 mg (0.3 mmol) (5-ethynyl-3-methyl-pyridin-2-yl)-(2-pyrrolidin-1-yl-ethyl)-amine and 95 mg (0.3 mmol) 5-(4-chloro-phenyl)-2-iodo-pyridine, while after working up the crude product is purified by chromatography on Alox (cyc/EtOAc 6:4).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618132B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-2fe416276d0f42a0bc1904923c1c3db9 |
| Source note | uspto-grants-2013_12 |