反应详情

温度

110 °C

A solution of 22.7 g (0.101 mol) 6-bromo-1H-quinolin-2-one in 380 mL 1,4-dioxane and 380 mL MeOH is combined with 141.5 ml (0.283 ml) 2 M Na2CO3 solution and saturated with argon. Then 3.735 g (3.23 mmol) tetrakis-triphenyl-phosphane-palladium and 4-chlorophenylboric acid are added successively. The reaction mixture is heated to 110° C. for four hours and then evaporated down to a volume of 300 mL. 1.2 L water are added and the precipitate is filtered off. The solid is dried at 55° C. in the drying cupboard, washed with diisopropylether and dried again.

1. customevaporated down to a volume of 300 mL
2. addition1.2 L water are added
3. filtrationthe precipitate is filtered off
4. customThe solid is dried at 55° C. in the drying cupboard
5. washwashed with diisopropylether
6. customdried again