Acetate → tert-Butyl 6-[(1-methyl-1H-pyrazol-5-yl)amino]-4-oxo-spiro[chroman-2,4'-piperidine]-1'-carboxylate

HRID 191682Notes

Reaction equation

HRID 191682 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[O:8][C:7]1([CH2:6][C:5]2=[O:24])[CH2:12][CH2:13][N:14]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:15][CH2:16]1.[C:32]([P:33]([C:34]([CH3:35])([CH3:36])[CH3:37])[c:38]1[cH:39][cH:40][cH:41][cH:42][c:43]1-[c:44]1[cH:45][cH:46][cH:47][cH:48][cH:49]1)([CH3:50])([CH3:51])[CH3:52].[C:53](=[O:54])([O-:55])[O-:56].[C:65]([O-:66])(=[O:67])[CH3:68].[C:70]([O-:71])(=[O:72])[CH3:73].[CH2:59]1[O:60][CH2:61][CH2:62][O:63][CH2:64]1.[Cs+:57].[Cs+:58].[NH2:25][c:26]1[cH:27][cH:28][n:29][n:30]1[CH3:31].[Pd+2:69]>>[c:2]1([NH:25][c:26]2[cH:27][cH:28][n:29][n:30]2[CH3:31])[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[O:8][C:7]1([CH2:6][C:5]2=[O:24])[CH2:12][CH2:13][N:14]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:15][CH2:16]1

Participants

9

Reactant 8

HCID 175Acetate2×HCID 19660Carbonate IonHCID 312751,4-DioxaneHCID 104967Cesium cation2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 1369272-Methyl-2H-pyrazol-3-ylamineHCID 27342152-(Di-tert-butylphosphino)biphenylHCID 2794759tert-Butyl 6-bromo-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate

Product 1

HCID 57931025tert-Butyl 6-[(1-methyl-1H-pyrazol-5-yl)amino]-4-oxo-spiro[chroman-2,4'-piperidine]-1'-carboxylate

Sources & evidence

ORD record
ord-b7d73d24648f494fb249d6dca50b78a6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

Loading…