Sodium Carbonate → HCID 67954032, compound

Participants

Reaction Steps

To a solution of compound 16-C (0.011 g, 0.27 mmol) in DMF (0.5 mL) was added Na2CO3 (0.0057 g, 0.054 mmol) and 4-fluoro-3-trifluoromethylbenzyl bromide (0.0077 g, 0.03 mmol). The reaction mixture was stirred at room temperature overnight. The reaction mixture was diluted with ethyl acetate, washed with water, and dried over sodium sulfate. The solvent was evaporated in vacuo and the residue was purified by flash column chromatography, eluting with a hexanes-EtOAc gradient to give Compound 102 (0.011 g, 72%) as a white solid; MS m/z (M+H+) 564.

Provenance & Evidence